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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPAR?) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity.

April 24, 2021 | Biological Trace Element Research | Oyagbemi AA, Adejumobi OA, Jarikre TA, Ajani OS, Asenuga ER, Gbadamosi IT, Adedapo ADA, Aro AO, Ogunpolu BS, Hassan FO, Falayi OO, Ogunmiluyi IO, Omobowale TO, Arojojoye OA, Ola-Davies OE, Saba AB, Adedapo AA, Emikpe BO, Oyeyemi MO, Nkadimeng SM, McGaw LJ, Kayoka-Kabongo PN, Oguntibeju OO, Yakubu MA. | [Epub ahead of print]

Dental Fluorosis in Children from Aguascalientes, Mexico: A Persistent Public Health Problem.

April 20, 2021 | Water | By Osiel González Dávila | 13(8):1125.
1. Introduction Dental fluorosis and skeletal fluorosis are major public health concerns around the world. Regions with a high prevalence of such illnesses have been recently documented in Asia, particularly in China [1,2,3,4], India [5,6,7,8], Pakistan [9,10,11], and Sri Lanka [12,13,14]. In Africa, dental fluorosis is prevalent mainly in Sub-Saharan countries, including Kenya, Tanzania, Uganda, Ethiopia, Eritrea, Sudan, Ghana, Malawi, Niger, Nigeria, Mozambique, and South Africa [15,16,

Voriconazole-induced periostitis

April 19, 2021 | Reumatismo | Fernández Ávila DC, Diehl M, Degrave AM, Buttazzoni M, Pereira T, Aguirre MA, Basquiera AL, Scolnik M. | 73(1):44-47.
The main hypothesis that explains how voriconazole can generate or trigger this periostitis is subacute fluoride toxicity, secondary to the use of the antifungal agent. Voriconazole contains in its structure three fluorine atoms that represent 16.25% of its molecular weight. This means that a dose of 400 mg contains 65 mg of fluorine (6). In addition, 5% is metabolized into free fluorine. The risk of skeletal effects is elevated in patients with fluoride intakes greater than 6 mg/day (7). When p

Fluoride in Drinking Water, Diet, and Urine in Relation to Bone Mineral Density and Fracture Incidence in Postmenopausal Women.

April 6, 2021 | Environmental Health Perspectives | Helte E, Donat Vargas C, Kippler M, Wolk A, Michaëlsson K, Åkesson A. | 129(4):47005
Exposure to fluoride occurs mainly through drinking water, which may include fluoride from natural sources and fluoride added to prevent tooth decay. Naturally occurring fluoride concentrations can vary substantially, from insignificant to well above the World Health Organization (WHO)-recommended limit of 1.5mg/L (WHO 2006), whereas the concentration in artificially fluoridated water is typically around 0.7mg/L (U.S. Department of Health and Human Services Federal Panel on Community Water Fluor