DNA methylation and fluoride exposure in school-age children: Epigenome-wide screening and population-based validation.
August 6, 2021
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Ecotoxicology and Environmental Safety
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Wang A, Ma Q, Gong B, Sun L, Afrim FK, Sun R, He T, Huang H, Zhu J, Zhou G, Ba Y.
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223:112612.
4. Discussion
Water-borne endemic fluorosis has been widely prevalent in China, especially in the central, western and northern parts of China. In order to explore the possible epigenetic changes caused by fluoride exposure, we conducted a screening and validation study in step by step. We undertook, for the first time, microarray analyses of DNA methylation on samples from school-age children who had been exposed to/not exposed to excessive fluoride in drinking water. Gradually, we conducted