About the month of April 1936 the district health officer, Nellore, Dr. Lakshminarayana, had his attention drawn by the health inspectors of Podili and Darsi ranges of the Nellore district to a disease characterized by a definite train of symptoms and which was very prevalent in the district. The most obvious symptoms of this disease were stiffness and pain in the spinal region and in various joints. Cattle were stated to be similarly affected. In August 1936, the district health offic
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THE endemic hypoplasia of the permanent teeth known in this country as mottled enamel was first reported by Eager in 1901. The first investigation in the United States was the extensive one of Black,2 and McKay,3 published in 1916. At present in this country alone there are more than 200 areas where endemic mottled enamel has been confirmed by survey; in addition there are approximately 100 areas where the endemicity has been reported but not confirmed by survey. These approximate 300 a
The following is the National Academy of Sciences' review of the draft NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects
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HUMAN EVIDENCE
NTP based its conclusion in the monograph primarily on human evidence. NTP considered the human evidence to be “relatively robust” and evaluated the association of fluoride exposure and neurodevelopmental and cognitive effects as reported in 82 publications. Although it evalu
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It has been generally accepted that a concentration of 1 per cent sodium fluoride is adequate to prevent glycolysis in nonprecipitated blood and that no appreciable glycolysis results if the blood proteins are precipitated within 5 minutes after the blood is drawn (1). Determinations of lactic acid in the blood precipitated within 5 minutes or preserved in 1 per cent sodium fluoride have yielded a range of 8 to 20 mg. per cent for normal subjects under basal conditions.
We have had o
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The first account of mottled enamel in human beings was given in 1902 by Eager of the United States Public Health Service who noticed its frequency among Italian emigrants from Naples. Black and McKay (1916) found it occurring in various parts of the U.S.A. and described it more fully in 1916. Since then, cases have been reported from every continent, but although popular belief associated the condition with drinking water, it was not till 1932 that fluorine contained in it was establis
