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Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Metabolism and Toxicity of Fluorine Compounds

January 29, 2021 | Chemical Research in Toxicology | Kyzer JL, Martens M. | 34:678?680.
Abstract Fluorine has many beneficial features and applications but can cause toxicity at high doses. Herein, we describe its chemical properties and benefits to agrochemical design as well as potential metabolic liabilities and exposure assessment in vivo.   The use of fluorine in drugs and agricultural chemicals has greatly expanded since the first fluoro compound, fludrocortisone, was approved in 1955. In 2018–2019, 45% of small molecule drugs approved by the U.S.