Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells.

February 18, 2020 | Science Signaling | Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner II LE, Idaghdour Y, Yule DI, Lacruz RS. | 13(619):eaay0086 DOI: 10.1126/scisignal.aay0086
How too much fluoride derails dentition Excessive fluoride ingestion during childhood results in defective tooth enamel mineralization, which can lead to dental problems later in life. Aulestia et al. investigated the molecular mechanisms underlying fluorosis in enamel-forming cells isolated from rats and in an enamel cell line. Exposure of enamel cells to fluoride resulted in decreases in ER Ca2+ content and store-operated Ca2+ entry into the ER, reduced the expression of genes encoding ER s

Fluoride exposure in public drinking water and childhood and adolescent osteosarcoma in Texas.

May 17, 2016 | Cancer Causes & Control | Archer NP, Napier TS, Villanacci JF. | 27(7):863-868. doi: 10.1007/s10552-016-0759-9.
References Mirabello L, Troisi RJ, Savage SA (2009) Osteosarcoma incidence and survival rates from 1973 to 2004: data from the surveillance, epidemiology, and end results program. Cancer 115(7):1531–1543. doi:10.1002/cncr.24121 Article PubMed PubMed Central Google Scholar Tucker MA, D’Angio GJ, Boice JD Jr, Strong LC, Li FP, Stovall M, Stone BJ, Green DM, Lombardi F, Newton W, Hoover RN, Fraumeni JF Jr (1987) Bone sarcomas linked to radiotherapy and chemo

Fluoride-induced rectal barrier damage and microflora disorder in mice.

December 29, 2019 | Environmental Science and Pollution Research International | Wang HW, Miao CY, Liu J, Zhang Y, Zhu SQ, Zhou BH. | doi: 10.1007/s11356-019-07201-8. [Epub ahead of print]
References Abdelqader A, Al-Fataftah AR, Da? G (2013) Effects of dietary Bacillus subtilis and inulin supplementation on performance, eggshell quality, intestinal morphology and microflora composition of laying hens in the late phase of production. Anim Feed Sci Technol 179(1-4):103–111. https://doi.org/10.1016/j.anifeedsci.2012.11.003 Apas AL, Arena ME, Colombo S, Gonzalez SN (2015) Probiotic administration modifies the milk fatty acid profile, intestinal morphology, and intestinal

Condition of mineralized tooth tissue in a population of 15-year-old adolescents living in a region of Ukraine with slightly exceeded fluorine concentration in the water.

December 19, 2019 | Annals of Agricultural and Environmental Medicine | Bachanek T, Hendzel B, Wolanska E, Samborski D, Jarosz Z, Pitura KM, Dzida K, Podymniak M, Tymczyna-Borowicz B, Niewczas A, Shybinskyy V, Zimenkovsky A. | 26(4):623-629. doi: 10.26444/aaem/110013.
Excerpt In the examined group, the average number of teeth with fluorosis was 7.59; 9.93 for girls and 5.08 for boys. Comparing the tests results, it was concluded that there were more teeth with fluorosis in the population of girls (median: 7; interquartile range: 4–16) than in the population of boys (median: 4; interquartile range: 2–6), which was statistically significant (p=0.038) (Tab. 6).

Detrimental Effects of Sodium Fluoride on the Expression of Insulin Receptor in the Olfactory Bulb and Hippocampus of Male Mice.

February 3, 2020 | Biological Trace Element Research | Yuan J, Li Q, Ommati MM, Niu R, Wang J. | doi: 10.1007/s12011-020-02053-7. [Epub ahead of print]
References Niu R, Chen H, Manthari RK, Sun Z, Wang J, Zhang J, Wang J (2018) Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus. Chemosphere 194:628–633 CAS PubMed Article Google Scholar Li J, Shi Y, Fan H, Li Y, Zhu Y, Lin X, Zhang J (2018) Effects of fluoride on surface structure of primary culture Leydig cells in mouse. Biol Trace Elem Res 183(1):123–127 CAS PubMed Article Google Scholar Zhao

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells.

January 25, 2020 | Biological Trace Element Research | Zhang Y, Zhou B, Tan P, Chen Y Miao C, Wang H. | https://doi.org/10.1007/s12011-019-01967-1
References Sun ZL, Xue XC, Zhang YL, Niu RY, Wang JD (2017) Effect of sodium fluoride on the sperm mitochondrial DNA in mice. Biochem Biophys Res Commun 492(3):295–299 CAS Article Google Scholar Niu RY, Wang JM, Sun ZL, Xue XC, Yan XY, Wang JM, Zhang JH, Wang JD (2015) Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride. Environ Toxicol Pharmacol 40(2):557–562 CAS Article