The fluoride permeation pathway and anion recognition in Fluc family fluoride channels.
July 12, 2021
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eLife
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McIlwain BC, Gundepudi R, Koff BB, Stockbridge RB.
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[Epub ahead of print]
Introduction
Microbes are protected from the cytoplasmic accumulation of environmental fluoride ion by export of the toxic anion via fluoride channels known as Flucs [1-3]. These small, homodimeric ion channels are remarkable proteins in two regards: first, their unusual “dual topology” architecture, in which the two subunits of the homodimer are arranged antiparallel with respect to each other [4,5], yielding a double-barreled pair of pores related by two-fold symmetry [6-9]. Second, the F