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NTP Research Report on Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies: Research Report 1 [Internet]

Background: Previous systematic reviews of epidemiology studies have found support for a geographical association between high levels of naturally occurring fluoride in water (>1.5 ppm) and lower IQ in children. Most of the evidence from humans is from fluoride-endemic regions having higher background levels of fluoride compared to the fluoride concentrations historically used in community water fluoridation programs (0.7–1.2 ppm). Confidence in this body of evidence is limited, prima