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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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The Dunedin Multidisciplinary Health and Development Study: Oral health findings and their implications.

February 4, 2020 | Journal of the Royal Society of New Zealand | Hong CL, Broadbent JM, Thomson WM, Poulton R. | 50(1):35-46.
Child oral health Early dental research from the Dunedin Study primarily focused upon the prevalence of childhood dental caries and its associated protective and causative factors, including community water fluoridation (which commenced in Dunedin in 1967, well before the Study members were born), self-care, and use of dental services. Over 90% of the Study participants had attended a School Dental Service (SDS) clinic by the age of 5 years, and more than half of those were enrolled with the SD

Detrimental Effects of Sodium Fluoride on the Expression of Insulin Receptor in the Olfactory Bulb and Hippocampus of Male Mice.

February 3, 2020 | Biological Trace Element Research | Yuan J, Li Q, Ommati MM, Niu R, Wang J. | doi: 10.1007/s12011-020-02053-7. [Epub ahead of print]
References Niu R, Chen H, Manthari RK, Sun Z, Wang J, Zhang J, Wang J (2018) Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus. Chemosphere 194:628–633 CAS PubMed Article Google Scholar Li J, Shi Y, Fan H, Li Y, Zhu Y, Lin X, Zhang J (2018) Effects of fluoride on surface structure of primary culture Leydig cells in mouse. Biol Trace Elem Res 183(1):123–127 CAS PubMed Article Google Scholar Zhao

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells.

January 25, 2020 | Biological Trace Element Research | Zhang Y, Zhou B, Tan P, Chen Y Miao C, Wang H. | https://doi.org/10.1007/s12011-019-01967-1
References Sun ZL, Xue XC, Zhang YL, Niu RY, Wang JD (2017) Effect of sodium fluoride on the sperm mitochondrial DNA in mice. Biochem Biophys Res Commun 492(3):295–299 CAS Article Google Scholar Niu RY, Wang JM, Sun ZL, Xue XC, Yan XY, Wang JM, Zhang JH, Wang JD (2015) Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride. Environ Toxicol Pharmacol 40(2):557–562 CAS Article

Biomarkers for the Assessment of Fluoride Exposure in Children.

January 21, 2020 | Caries Research | Idowu OS, Duckworth RM, Valentine RA, Zohoori FV. | doi: 10.1159/000504166. [Epub ahead of print]
References Bashash M, Thomas D, Hu H, Martinez-Mier EA, Sanchez BN, Basu N, et al. Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico. Environ Health Perspect. 2017 Sep;125(9):097017. Bashash M, Marchand M, Hu H, Till C, Martinez-Mier EA, Sanchez BN, et al. Prenatal fluoride exposure and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12years of age in Mexico City. Environ Int. 2018 Dec;121(Pt 1):658-