Tag: Osteoid
Showing 9 of 9:
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Experimental osteofluorosis and arthrofluorosis in rats
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Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats
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Bone mineral structure after six years fluoride treatment investigated by backscattered electron imaging (BSEI) and small angle x-ray scattering (SAXS): a case report
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Ministry of not-so-funny walks
The fluorosis problem is “enormous, unbelievable,” says Andezhath Susheela of the Fluorosis Research and Rural Development Foundation in Delhi. She has been unravelling the national story for a decade during which time her estimate of the number of people leading “a painful and crippled life” from fluorosis has risen from one million to 25 million and now to 60 million — six million of them children.
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Fluoride’s Effect on Osteoblasts (Bone-Forming Cells)
As noted by the National Research Council, “[p]erhaps the single clearest effect of fluoride on the skeleton is its stimulation of osteoblast proliferation.” (NRC 2006). Osteoblasts are bone-forming cells. “Stimulatory effects of fluoride on osteoblasts result in formation of osteoid, which subsequently undergoes mineralization.” (Fisher RL, et al. 1989). If the new osteoid tissue is subsequently mineralized, […]
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Fluoride Exposure Increases Metabolic Requirement for Calcium & Vitamin D
It is well known that individuals with nutrient deficiencies are more susceptible to fluoride toxicity, including fluoride’s bone effects. As discussed in the following studies, fluoride increases the skeleton’s need for calcium (and vitamin D) by increasing the amount of unmineralized tissue (osteoid) in the bone. When insufficient calcium and vitamin D is available to […]
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Fluoride & Rickets
One of fluoride’s most well-defined effects on bone tissue is it’s ability to increase the osteoid (unmineralized bone) content of bone. When bones have too much osteoid, they become soft and prone to fracture — a condition known as osteomalacia. When osteomalacia develops during childhood, it is called “rickets.” The potential for fluoride to cause rickets was first […]
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Fluoride Increases Osteoid Content of Bone
Fluoride’s ability to increase the osteoid content of bone is now undisputed. Osteoid is an unmineralized tissue in bone that, in the normal bone remodeling process, ultimately becomes calcified. As some observers have noted, “[t]he main histological change induced by fluoride is the increase of osteoid volume.” (Arnala 1985). One way fluoride is believed to cause […]
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Similarities between Skeletal Fluorosis and Renal Osteodystrophy
It is quite possible, and indeed likely, that some kidney patients diagnosed with renal osteodystrophy are either suffering from skeletal fluorosis or their condition is being complicated/exacerbated by fluoride exposure.