Tag: Pharmaceuticals
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Voriconazole-Associated Periostitis: New Insights into Pathophysiology and Management.
1. Introduction Voriconazole is a frequently used antifungal in the post-transplant setting and has been associated with periostitis with long-term use.( 1 ) The true prevalence of voriconazole-associated periostitis (VAP) is unknown; however, retrospective studies suggest this adverse effect may occur in up to 15% of patients on voriconazole.( 1 , 2 , 3 ) […]
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Chemical Aspects of Human and Environmental Overload with Fluorine
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Optimal trough concentration of voriconazole with therapeutic drug monitoring in children: A systematic review and meta-analysis.
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Metabolism and Toxicity of Fluorine Compounds
Abstract Fluorine has many beneficial features and applications but can cause toxicity at high doses. Herein, we describe its chemical properties and benefits to agrochemical design as well as potential metabolic liabilities and exposure assessment in vivo. The use of fluorine in drugs and agricultural chemicals has greatly expanded since the first fluoro compound, […]
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary maximum contaminant level […]
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Fluorosis by the Ministry of Health & Family Welfare, National Health, India.
Introduction Fluorosis is a crippling disease resulted from deposition of fluorides in the hard and soft tissues of body. It is a public health problem caused by excess intake of fluoride through drinking water/food products/industrial pollutants over a long period. Ingestion of excess fluoride, most commonly in drinking-water affects the teeth and bones. It results […]
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Flutemetamol F 18. Summary of Use during Lactation.
Drug Levels and Effects Information in this record refers to the use of flutemetamol F 18 as a diagnostic agent. No information is available on the use of flutemetamol F 18 during breastfeeding. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose of 185 MBq (5 mCi). This length of time is […]
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Florbetaben F 18: Summary of Use during Lactation.
Drug Levels and Effects Information in this record refers to the use of florbetaben F 18 as a diagnostic agent. No information is available on the use of florbetaben F 18 during breastfeeding. The manufacturer recommends withholding breastfeeding for 24 hours after a diagnostic dose Twenty-four hours is about 10 half-lives of fluoride F 18 […]
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A case of skeletal fluorosis? (Letter)
A 79-year-old lady presented with a history of diffuse sero-negative arthritis dating from early adulthood. Numerous investigations and therapies had failed to provide any significant benefit and both knees and a hip had been replaced when initially seen a year ago. On questioning at that time, she admitted to daily drinking at least six cups […]
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Elevated fluoride levels and periostitis in pediatric hematopoietic stem cell transplant recipients receiving long-term voriconazole