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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Condition of mineralized tooth tissue in a population of 15-year-old adolescents living in a region of Ukraine with slightly exceeded fluorine concentration in the water.

December 19, 2019 | Annals of Agricultural and Environmental Medicine | Bachanek T, Hendzel B, Wolanska E, Samborski D, Jarosz Z, Pitura KM, Dzida K, Podymniak M, Tymczyna-Borowicz B, Niewczas A, Shybinskyy V, Zimenkovsky A. | 26(4):623-629. doi: 10.26444/aaem/110013.
Excerpt In the examined group, the average number of teeth with fluorosis was 7.59; 9.93 for girls and 5.08 for boys. Comparing the tests results, it was concluded that there were more teeth with fluorosis in the population of girls (median: 7; interquartile range: 4–16) than in the population of boys (median: 4; interquartile range: 2–6), which was statistically significant (p=0.038) (Tab. 6).

Detrimental Effects of Sodium Fluoride on the Expression of Insulin Receptor in the Olfactory Bulb and Hippocampus of Male Mice.

February 3, 2020 | Biological Trace Element Research | Yuan J, Li Q, Ommati MM, Niu R, Wang J. | doi: 10.1007/s12011-020-02053-7. [Epub ahead of print]
References Niu R, Chen H, Manthari RK, Sun Z, Wang J, Zhang J, Wang J (2018) Effects of fluoride on synapse morphology and myelin damage in mouse hippocampus. Chemosphere 194:628–633 CAS PubMed Article Google Scholar Li J, Shi Y, Fan H, Li Y, Zhu Y, Lin X, Zhang J (2018) Effects of fluoride on surface structure of primary culture Leydig cells in mouse. Biol Trace Elem Res 183(1):123–127 CAS PubMed Article Google Scholar Zhao

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells.

January 25, 2020 | Biological Trace Element Research | Zhang Y, Zhou B, Tan P, Chen Y Miao C, Wang H. | https://doi.org/10.1007/s12011-019-01967-1
References Sun ZL, Xue XC, Zhang YL, Niu RY, Wang JD (2017) Effect of sodium fluoride on the sperm mitochondrial DNA in mice. Biochem Biophys Res Commun 492(3):295–299 CAS Article Google Scholar Niu RY, Wang JM, Sun ZL, Xue XC, Yan XY, Wang JM, Zhang JH, Wang JD (2015) Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride. Environ Toxicol Pharmacol 40(2):557–562 CAS Article