Conclusions and Perspectives
The results obtained so far on the cellular mechanism by which fluoride may influence the growth and differentiation of osteoblastic cell lines strongly suggest alteration of one or several G protein-dependent tyrosine phosphorylation process(es), activation of the ERK, and possibly other signaling pathways. There is a controversy of whether enhancement of tyrosine phosphorylation induced by fluoride results from inhibition of tyrosine phosphatase(s) or activation
The familial pituitary or central diabetes insipidus (DI) is a relatively rare condition with variable onset, from birth to several years of age and variable severity within a family and in individuals over time(l). Severe dehydration and growth retardation, though rare are known compilations of DI. However, dental fluorosis as a complication of DI has been described in the literature only in three families(2,3). Further, severe crippling deformities due to skeletal fluorosis has not been report