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Micronucleus and sister chromatid exchange frequency in endemic fluorosis

Introduction Although widespread in occurrence, fluorine (as fluoride ion, F-) does not have any known physiological requirement. It is generally accepted, however, that long term over-intake of fluoride may cause skeletal as well as dental fluorosis. Many studies on other toxic effects of fluoride have been made, including whether it alters human genetic material and ultimately leads to more serious harm. (1) At present, various test systems and methods have been developed to detect fluoride