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Time trends for bone and joint cancers and osteosarcomas in the Surveillance, Epidemiology and End Results (SEER) Program

At the request of the Committee, we have enclosed a brief description of the time trends for bone and joint cancers and for osteosarcomas in the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute (NCI), and the relationship of these trends to fluoridation of drinking water supplies. The SEER Program, begun in 1973, is a group of population-based cancer registries that covers approximately 10% of the U.S. population. In contrast to our main report which foc

Distribution of fluoride to human breast milk following intake of high doses of fluoride.

Excerpt The present study demonstrates that, in spite of the high fluoride dose administered to the mother (11.25 mg), the child receives a maximum dose of 30 ug fluoride/day, or 0.2% of the dose given to the mother. This is only 3% of the dose compared with the daily fluoride dose to bottle-fed children. With a baby formula diluted with 1 ppm fluoride water, bottle-fed children receive approximately 1 mg/day. In conclusion, this study shows that there is a slight increase in the fluoride co

No evidence of transfer of fluoride from plasma to breast milk.

Artificially fluoridated drinking water is supplied throughout the world as a mass-prophylactic against dental caries. No data are available, however, on the transfer of fluoride from maternal plasma to breast milk. We have therefore compared the fluoride concentration in the plasma and breast milk of nursing mothers after an oral dose of fluoride. Subjects and Methods Five mothers aged 27-36 years were given fluoride by mouth on the third postpartum day. A dose of 1.5 mg was given as an a