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Influence of sodium fluoride and caffeine on the concentration of fluoride ions, glucose, and urea in blood serum and activity of protein metabolism enzymes in rat liver.

In our experiment, we found a statistically insignificant increase of glucose concentration in blood serum, by 12% (group with F–) and by 17% (group with F– + caffeine). The increase of glucose concentration influenced by F– is known. It is connected with the concentration of NaF administered, although even with low doses of F– the concentration of glucose in serum might increase. It is probable that fluorides intensify the glucogenetic processes.