References
1.Bawden J.W., Wolkoff A.S., Flowers Jr., C.E. PLACENTAL TRANSFER OF F18 IN SHEEP. J. Dent. Res. 1964; 43: 678.
2. Clark E.P., Collip J.B. J. A STUJ;)Y OF THE TISDALL METHOD FOR THE DETERMINATION OF BLOOD SERUM CALCIUM WITH A SUGGESTED MODIFICATIONBiol. Chem. 1925; 63: 461. - Full Text PDF
3. Denzer B.S., Reiner M., Weiner S.B. Amer. J. Dis. Child. 1939; 57: 809. Google Scholar
4. Gedalia I., Bryzezinski A., Bercovici B., Lazaron E. ed. 2. Proc. Soc. Exp. Biol. Med
The onset of chronic fluorosis is insidious and may be confused with chronic debilitating diseases such as osteoarthritis . . .
* https://pubmed.ncbi.nlm.nih.gov/5463662/
The concept that osteomalacia becomes progressively worse on chronic dialysis was reinforced by the findings in the repeat bone biopsies in that 6 of the 8 patients showed a significant increase in their osteoid index. . . . Thus, the progression of osteomalacia appears to be the main reason for the increasing incidence of bone pain and pseudofractures which we and others have observed in patients on chronic dialysis for periods longer than 6 months. Jowsey, et al, has reported similar findings.
Summary
Chronic fluorosis alters bone structure, leads to odd exostosis, to osseous appositions, to ossification of ligaments and tendons and their insertions. This can cause pain and discomfort. Radiological examination usually leads to the correct diagnosis; the most constant changes were found in films of elbows and forearms. Such films may be useful in the diagnosis of industrial fluorosis and perhaps for detecting undesirable effects of prolonged fluoride therapy. It seems clear that man
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