We appreciate your patience as we fix inconsistencies in the study tracker and research databases.

Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
  • Health Category:
  • Health Sub-Category:

  • Study Type:

  • Publish Date:

    -

Neurotoxicity induced by fluoride in rat cerebral cortex

October 2016 | International Journal of Current Microbiology and Applied Sciences | Shashi A and Kumar J. | 5(10):938-951.
In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in neuroplasm and others were showing necrosis. Some granule cells were swollen in shape and size (Fig. 5). ... In rats treated with 200 ppm of sodium flu

The effects of fluoride on neuronal function occurs via cytoskeleton damage and decreased signal transmission

October 2017 | Chemosphere | Chen L, Ning H, Yin Z, Song X, Feng Y, Qin H, Li Y, Wang J, Ge Y, Wang W. | 185:589-594.
In conclusion, the effects of NaF on a cell’s survival and integrity suggested that different concentrations NaF had direct toxic effects on the Neuro-2A cell line. NaF not only reduced the expression of select axonal proteins, but also prevented the secretion and delivery of the neurotransmitter glutamate.We found that expression of glutamate and its receptor, NMDAR, decreased with increasing dosages of NaF. Presumably, NaF can influence the generation and functions of axons, and limit

Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity.

February 2018 | Environmental Pollution | Niu Q, Chen J, Xia T, Li P, Zhou G, Xu C, Zhao Q, Dong L, Zhang S, Wang A. | 233:889-899.
from 4. Discussion ... In order to gain a better understanding of the NaF neurotoxicity and its underlying mechanisms, the NaF-treated rats and SH-SY5Y cells were used in the present study. The MWM [Morris water maze test] results showed that exposure of rats to NaF is associated with decreased learning and memory abilities. This is consistent with previous studies where animals exposed to fluoride with similar dosages and duration can also demonstrated different characteristics of neurotoxic

Effect of fluoride on brain of albino-rabbit – An experimental study.

December 2017 | International Journal of Applied Research | Sahu SK, Pradham S, Sahu MC. | 3(3):818-821.
From Table 1: Gross and brain cyto-architecture changes of experimental animals at the end of 16 weeks. Changes in Brain Cytoarchitecture: The neurones lost their angular or pyramidal shape and acquired a plump, ovoid, rounded, or characteristic "ballooned" appearance (Figure 1). The nucleus was displaced to the periphery or axonal base and was shrunken, pyknotic, or absent. Reduction in the number of Purkinje neurones and in some areas even complete loss of neurones. Pyramidal neurones exhib