On the grounds of the results obtained during our experiments F compounds are able to produce certain changes in chromosomes from somatic cells of animals treated in vivo by them… Most of the aberrations observed in the case of bone marrow cells were chromatid-type aberrations… [W]e entertain the opinion that the main damage to chromosomes during our experiments with F compounds also took part during the S-phase… [T]hese data enable us to consider as sufficiently established the conclusion
Summary
These data show that:
1. During a 2 year period, the chronic use of fluoridated water in patients undergoing maintenance hemodialysis was associated with a rise in serum phosphatase in 10 of 20 patients studied and an increased radiographic incidence of osteodystrophy.
2. Eight long-term hemodialysis patients manifested no radiographic evidence of osteodystrophy during their first 2 to 6 years of hemodialysis, and one of these patients currently has a negative bone survey, 9 years aft
