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Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride Transport and Inhibition Across CLC Transporters.

August 31, 2022 | Handbook of Experimental Pharmacology | Asgharpour S, Chi LA, Spehr M, Carloni P, Alfonso-Prieto M. | pp 1-20. [Epub ahead of print]
Notes 1. Fluoride is isosteric with hydroxide and can compete with phosphate and carboxylate groups, thus acting as a substrate- or transition state-like inhibitor of several enzymatic reactions (Strunecka and Strunecky 2020). 2. Higher organisms can avoid fluoride’s harmful effects, thanks to the exquisite selectivity of most of their anion channels and transporters, which limits fluoride resorption in the gastrointestinal tract (Johnston and Strobel 2020). 3. Larger anions, su