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Further development of mathematical description for combined toxicity: A case study of lead–fluoride combination.

Highlights Rats were exposed during 6 weeks to repeated i.p. injections of lead acetate, sodium fluoride or both in doses 0.05 LD50. The development of intoxication was estimated quantitatively with 54 functional, biochemical and morphometric indices. For mathematical description of effects a response surface regression model containing linear and cross terms was used. 10 types of combined action were found thus confirming the result of the similar study on Pb and Cd.