Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride studies in a patient with arthritis

October 9, 1971 | The Lancet | Cook HA. | 298(7728):817.
SIR, A high intake of fluoride (F-) is known to cause severe skeletal fluorosis, but the actual fluoride intake required to produce fluorosis is unknown. I have shown that tea-drinking in Britain causes a high intake in both children and adults, maximum intakes in children surveyed reaching nearly 6 mg daily in unfluoridated areas and nearly 7 mg daily in fluoridated areas. (1) It is possible that fluoride intake from tea may be sufficient to cause fluorosis, and I report here a case which gives

Skeletal fluorosis mimicking seronegative spondyloarthropathy: a deceptive presentation

October 2011 | Tropical Doctor | Kumar S, Kakar A, Gogia A, Byotra SP. | 41:247-48.
Case history A 40-year-old man presented with a history of continuous pain in his back for one year and knee and elbow joints for nine months. It was associated with early morning stiffness lasting for 15 min. He had also begun to have difficulty walking. He was a driver by profession and revealed that he had difficulty in getting out of the driver’s seat after driving for long periods. There was no history of redness in his eyes, he had no skin manifestations and his bowel and bladder were

Experimental fluorosis in rats: NaF induced changes of bone and bone marrow

April 1983 | Fluoride | Bely M. | 16(2):106-11.
The results of our experiments suggest that increased doses of NaF cause more extensive osteosclerosis due to the decrease in number and/or activity of osteoclasts. Therefore oateosclerosis is caused primarily, not by increased bone formation but, by the inhibition of bone resorption. This view is supported by the fact that fluoride inhibits acid phosphatase activity more than alkaline phosphatase (6). The acid phosphatase activity of osteoclasts is of greater inteneiry than that of osteoblasts