Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress.

September 19, 2009 | Toxicology | García-Montalvo EA, Reyes-Pérez H, Del Razo LM. | 263(2-3):75-83.
The F group experienced higher significant increases in serum glucose concentration than those of control mice at 60, 90, 120 and 240min after administration of glucose. The differential analysis of the AUC of the response obtained with the [oral glucose tolerance test] shows a significant increase of 22.8% in the F exposed group.

Absence of detrimental effects of fluoride exposure in diabetic rats.

February 1996 | Archives of Oral Biology | Dunipace AJ, Wilson CA, Wilson ME, Zhang W, Kafrawy AH, Brizendine EJ, Miller LL, Katz BP, Warrick JM, Stookey GK. | 41(2):191-203.
The one histological variable on which fluoride did exert an effect in the diabetic animals was the width of the cortex in the tibia. Loss of bone mass and density are characteristic of both experimental and human diabetes and were evident in our diabetic animals in which the diaphyseal bone width was significantly less than in controls treated with 0, 5 or 15 parts/10^6 fluoride [ppm].