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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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A role of fluoride on free radical generation and oxidative stress in BV-2 microglia cells.

August 13, 2012 | Mediators of Inflammation | Shuhua X, Ziyou L, Ling Y, Fei W, Sun G. | Volume 2012, Article ID 102954
In conclusion, a main finding of this study was that microglia BV-2 cells were activated by fluoride, and the increase of ROS and RNS in microglia was associated with the activation of microglia. The novelty of this work is related to the active role of microglia treated with fluoride. We provided new evidence from in vitro model indicating that fluoride exerts its toxic effects in CNS possibly partly ascribed to activating of microglia in vitro, which enhanced oxidative stress induced by ROS an