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Absence of detrimental effects of fluoride exposure in diabetic rats.

The one histological variable on which fluoride did exert an effect in the diabetic animals was the width of the cortex in the tibia. Loss of bone mass and density are characteristic of both experimental and human diabetes and were evident in our diabetic animals in which the diaphyseal bone width was significantly less than in controls treated with 0, 5 or 15 parts/10^6 fluoride [ppm].