Bone tissue from rats drinking fluoridated water has been investigated by contact microradiography and x-ray fluorescence technique. At high dosages (1 mg F/day) osteosclerosis is seen within a year; later, resorption cavities occur. At more moderate dosages (0.3 mg F/day) no osteosclerosis is seen but resorption cavities sometimes occur, however. No resorption cavities are seen in the skeleton from rats with a fluorine intake of less than 0.1 mg F/day.
Summary
1. The skeletal changes in endemic fluorosis are described from an area of the Punjab where the fluorine content of water and soil is very high.
2. A detailed description of a fluorotic skeleton is given, with its various anthropometric measurements.
3. The vertebral changes demonstrated the pathogenesis of the neurological complications observed in this condition.
At all ages 7.1 per cent of white children with continuous residence, and 15.9 per cent of Negro children with the same history, showed one of the positive signs of fluorosis--very mild or mild in degree. About the same proportions--7.7 and 14.1 percent, respectively--were found in children aged 12 to 14 years. Community fluorosis indices as defined by Dean, were .14 and .33 for white and Negro children of all ages with continuous residence, and .15 and .31, respectively, for continuous-resident
Based on several studies, national standard GOST 2874-54 established the maximum allowable concentration of fluorine in drinking water to be 1.5 mg/l. However, this standard cannot be considered sufficiently substantiated. Despite the fact that fluorine exhibits strong neurotropic activity, the question pertaining to the functional state of the nervous system as a result of the long-term intake of fluorine in the drinking water has remained open. Moreover, several indications of endemic fluorosi
SUMMARY
Data is presented showing that fluoride ingested by gravid women enters the maternal circulation, is stored in the placenta and passes through the placental barrier to enter the foetal blood supply.
Evidence is presented that the fluoride in the foetal blood supply affects the developing teeth to make them more resistant .to dental caries. No unusual effects have been observed on the blood pictures of children who ingested fluoride.
One percent of our cases presented evidence of u
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ALBERTA lags behind most of the other provinces in Canada in instituting fluoridation as a public health measure for preventing tooth decay although the University of Alberta was the first institution in Canada to carry out significant research on this subject. The discovery that fluorine in water could prevent dental caries was first made in 1931 by research workers in the United States and as early as 1935 the travelling public health clinic in Alberta reported opaque white
