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Fluoride enhances generation of reactive oxygen and nitrogen species, oxidizes hemoglobin, lowers antioxidant power and inhibits transmembrane electron transport in isolated human red blood cells.

References Abbas et al., 2017. M. Abbas, M.H. Siddiqi, K. Khan, K. Zahra, A.U. NaqviHaematological evaluation of sodium fluoride toxicity in oryctolagus cunniculus. Toxicol. Rep., 4 (2017), pp. 450-454. Article. Adedara et al., 2017. I.A. Adedara, T.J.D. Ojuade, B.F. Olabiyi, U.F. Idris, E.M. Onibiyo, O.F. Ajeigbe, E.O. Farombi. Taurine ameliorates oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride. Biol. Trace Elem. Res., 175 (2) (2017), pp. 388-3

Engineered fluoride sensitivity enables biocontainment and selection of genetically-modified yeasts

References Hayden, E. C. Synthetic-biology firms shift focus. Nature 505, 598 (2014). ADS  PubMed  Article  CAS  PubMed Central  Google Scholar Li, M. & Borodina, I. Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae. FEMS Yeast Res. 15, 1–12 (2015). PubMed  Article  CAS  PubMed Central  Google Scholar Collins, J. J. & Khalil, A. S. Synthetic biology: applications come of age. Nat. Rev. Genet. 11, 367