At 3 months in the cerebellum, most of the neurons had normal cell structures and only a few Purkinje cell irregularities were notable, such as cell swelling and balloon-like cells in rats subjected to 30 ppm fluoride. In the cerebrum and hippocampus, no neuronal damage
was observed in rats exposed to 30 ppm fluoride. However, neurodegenerative changes were seen in the neurons of the rats exposed to 100 ppm fluoride. In the cerebellum, cell structure irregularities and Purkinje cell swelling we
In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in neuroplasm and others were showing necrosis. Some granule cells were swollen in shape and size (Fig. 5).
... In rats treated with 200 ppm of sodium flu
