We appreciate your patience as we fix inconsistencies in the study tracker and research databases.

Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
  • Health Category:
  • Health Sub-Category:

  • Study Type:

  • Publish Date:

    -

Effects of fluoride on the proliferation and activation of osteoblasts by regulating methylation of the DNA repair genes MGMT and MLH1.

February 14, 2022 | Regenerative Therapy | Chen L, Yin N, Ding Y, Zhang ML, Li M, Zhong JJ, Feng SM. | 19:107-112.
Introduction Fluoride can induce the proliferation and activation of osteoblasts, resulting in skeletal fluorosis progression; however, the specific mechanism is unclear. Methods Cell proliferation was examined using the MTT assay. Flow cytometry was performed to detect the cell cycle distribution. Alkaline phosphatase (ALP) was calculated to evaluate bone formation and turnover. Gene methylation was examined using the MSP assay. mRNA and protein expression levels were assessed us

Environmental exposures and pediatric kidney function and disease: A systematic review.

July 17, 2017 | Environmental Research | Zheng LY, Sanders AP, Saland JM, Wright RO, Arora M. | 158:625-648.
Two studies investigated the association of fluoride exposure, including 1 cross-sectional and 1 case-control. In a cross-sectional study of fluoride exposure in 210 children in China, the investigators found increases of urine NAG and urine ?-GT levels (Liu et al., 2005). In case-control study of fluoride levels in 210 children in China, slightly higher urine NAG levels were found in participants with higher serum fluoride levels (Xiong et al., 2007). While both studies were from China, the f

WITHDRAWN: Community-based population-level interventions for promoting child oral health.

December 22, 2016 | The Cochrane Database of Systematic Reviews | de Silva AM, Hegde S, Akudo Nwagbara B, Calache H, Gussy MG, Nasser M, Morrice HR, Riggs E, Leong PM, Meyenn LK, Yousefi-Nooraie R. | 12:CD009837.
Discussion Summary of main results This review includes 38 studies of community-based population-level interventions for promoting child oral health, with a total of 119,789 children. Interventions were generally implemented for less than one year (n = 26), and about half (n = 11) of studies were randomised controlled trials. Investigators tested a variety of oral health promotion strategies: dietary interventions (n = 3), oral health education alone (n = 17), oral health education in comb