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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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The association between fluoride in water and blood pressure in children and adolescents.

February 21, 2022 | Pediatric Research | Koh S. and Park S. |
References Flynn, J. T. et al. Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics 140, e20171904 (2017). PubMed  Google Scholar Ostchega, Y. et al. Trends of elevated blood pressure among children and adolescents: data from the National Health and Nutrition Examination Survey1988-2006. Am. J. Hypertens. 22, 59–67 (2009). PubMed  Google Scholar Leng, B., Jin, Y., Li, G., Chen, L. & Jin, N

The Effects of Vitamin D Application on NaF-Induced Cytotoxicity in Osteoblast Cells (hFOB 1.19).

March 10, 2022 | Biological Trace Element Research volume | Dede S, Taspinar M, Yüksek V, Çetin S, Usta A. | [Epub ahead of print]
Agalakova NI, Gusev GP (2012) Molecular mechanisms of cytotoxicity and apoptosis induced by inorganic fluoride. ISRN Cell Biol 403835. https://doi.org/10.5402/2012/403835 Perumal E, Paul V, Govindarajan V, Panneerselvam L (2013) A brief review on experimental fluorosis. Toxicol Letter 233:236–251. https://doi.org/10.1016/j.toxlet.2013.09.005 - DOI Song GH, Gao JP, Chun FW et al (2014) Sodium fluoride induces apoptosis in the kidney of rats through ca

Salivary fluoride concentration following toothbrushing with and without rinsing: a randomised controlled trial.

March 3, 2022 | BMC Oral Health | Albahrani MM, Alyahya A, Qudeimat MA, Toumba KJ. | 22(1):53.
References Marinho VC, Higgins JP, Sheiham A, Logan S. Fluoride toothpastes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2003;(1):CD002278. Marinho VCC. Cochrane reviews of randomized trials of fluoride therapies for preventing dental caries. Eur Arch Paediatr Dent. 2009;10(3):183–91. Article  Google Scholar Levine RS. What concentration of fluoride toothpaste should dental teams be recommending? Evid Based Dent. 2019;20(

Association of Dietary Calcium Intake with Dental, Skeletal and Non-Skeletal Fluorosis among Women in the Ethiopian Rift Valley.

February 14, 2022 | International Journal of Environmental Research and Public Health | Mulualem D, Hailu D, Tessema M, Whiting SJ. | 19(4):2119.
1. Introduction Drinking water sources in the Rift Valley of Ethiopia contain fluoride (F) levels exceeding the World Health Organization (WHO) limit of 1.5 mg/L [1,2]. As a consequence, many people living in the region are severely affected by fluorosis [2,3,4,5,6,7,8]. In serious cases, dental fluorosis is manifested as brown mottling of the enamel and results in overall yellowing of the teeth with erosion of the enamel [2,8]. Skeletal fluorosis occurs when there is a high degree

Fluoride induces hypomethylation of BMP2 and activates osteoblasts through the Wnt/B-catenin signaling pathway.

February 23, 2022 | Chemico-Biological Interactions | Chen L, Yin N, Ding Y, Zhang ML, Li M, Zhong JJ, Feng SM. | [Epub ahead of print]
Introduction Fluorine is a necessary trace element for the normal development of human organs, but long-term exposure of fluorine will result a fluorosis [1,2]. Appropriate amount of fluoride has positive effects on teeth and bones, but long-term excessive intake can cause severe damage [3], leading to dental fluorosis and skeletal fluorosis [[4], [5], [6], [7]]. Patients with skeletal fluorosis display multiple bone lesions, such as osteoporosis, osteosclerosis, calcification of ligament