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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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A concurrent exposure to arsenic and fluoride from drinking water in Chihuahua, Mexico.

April 24, 2015 | International Journal of Environmental Research and Public Health | González-Horta C, Ballinas-Casarrubias L, Sánchez-Ramírez B, Ishida MC, Barrera-Hernández A, Gutiérrez-Torres D, Zacarias OL, Saunders RJ, Drobná Z, Mendez MA, García-Vargas G, Loomis D, Stýblo M, Del Razo LM. | 12(5):4587-601.
"... significant differences were found in U-tAs and U-F- levels between males and females. Specifically, urine from women contained on average less tAs (41.5 vs 59.4 ng/mL) and F- (1.9 vs 2.4 µg/mL) than urine of men. "Notably, both signs of dental fluorosis and skin lesions typical of the chronic iAs exposure (keratosis and changes in pigmentation) were observed in several participants during the introductory medical exam (unpublished data). Previously, dental fluorosis was reported for 80

Small molecule fluoride toxicity agonists

April 23, 2015 | Chemistry & Biology | Nelson JW, Plummer MS, Blount KF, Ames TD, Breaker RR. | 22(4):527-34.
INTRODUCTION Although fluoride is commonly added to oral hygiene products to increase the strength of tooth enamel, it also has substantial anti-bacterial effects (Barbier et al., 2010; Li, 2003). For example, when in complex with a divalent metal ion and ADP, fluoride forms a nonfunctional mimic of ATP that can inhibit enolase (Curran et al., 1994; Qin et al., 2006), and similar complexes can inhibit a large diversity of other metabolic enzymes including phosphatases (Barbier et al., 2010; N