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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Increased fluoride content in the femur growth plate and cortical bone of uremic rats

September 2000 | Pediatric Nephrology | Mathias RS, Amin U, Mathews CH, Denbesten P. | 14(10-11):935-9
In summary, we demonstrate an increased F– content in the growth plate region of the femur at 4 weeks and 8 weeks, and in cortical bone at 8 weeks, in rats with experimental CRI. We hypothesize that elevated serum F– levels might contribute to the disturbances in mineral ion homeostasis that are observed in patients with CRI. This is of particular concern since the incidence of dental fluorosis has increased due to increased F– uptake from multiple fluoridated sources [24]. The ubiquitous

The effect of fluoride on enamel and dentin formation in the uremic rat incisor

November 2008 | Pediatric Nephrology | Lyaruu DM, Bronckers AL, Santos F, Mathias R, DenBesten P. | 23(11):1973-9
In summary, these studies show that tooth development is disturbed under uremic conditions. The effects of uremia are primarily in the dentin but also occur in enamel, resulting in hypoplasia and pitting of the enamel surface. The crown portion of human central incisors (the most aesthetically visible teeth) forms up to approximately 4 years of age, with the second permanent molars forming by about 8 years of age. Therefore, children who present with renal insufficiency before the age of 8 years