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Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Analysis of the MicroRNA Profile by Sequencing in Ovarian Granular Cells from Women Suffering Fluorosis with Reproductive Dysfunction.

December 14, 2019 | Biological Trace Element Research | Wang Z, Dong S, Chen Q, Chen C, Xu Z, Dong Z. | [Epub ahead of print]
References Dehghani MH, Haghighat GA, Yousefi M (2018) Data on fluoride concentration in drinking water resources in Iran: a case study of Fars province; Larestan region. Data in Brief 19:842–846. https://doi.org/10.1016/j.dib.2018.05.112 Article PubMed PubMed Central Google Scholar Dhurvey V, Thakare M (2016) The effect of sodium fluoride intoxication on the estrous cycle and ovarian hormones in rats. Fluoride 49:223–232 CAS Google Scholar

Fluoride exposure alters Ca2+ signaling and mitochondrial function in enamel cells.

February 18, 2020 | Science Signaling | Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner II LE, Idaghdour Y, Yule DI, Lacruz RS. | 13(619):eaay0086 DOI: 10.1126/scisignal.aay0086
How too much fluoride derails dentition Excessive fluoride ingestion during childhood results in defective tooth enamel mineralization, which can lead to dental problems later in life. Aulestia et al. investigated the molecular mechanisms underlying fluorosis in enamel-forming cells isolated from rats and in an enamel cell line. Exposure of enamel cells to fluoride resulted in decreases in ER Ca2+ content and store-operated Ca2+ entry into the ER, reduced the expression of genes encoding ER s

Key Role of Pro-inflammatory Cytokines in the Toxic Effect of Fluoride on Hepa1-6 Cells.

January 25, 2020 | Biological Trace Element Research | Zhang Y, Zhou B, Tan P, Chen Y Miao C, Wang H. | https://doi.org/10.1007/s12011-019-01967-1
References Sun ZL, Xue XC, Zhang YL, Niu RY, Wang JD (2017) Effect of sodium fluoride on the sperm mitochondrial DNA in mice. Biochem Biophys Res Commun 492(3):295–299 CAS Article Google Scholar Niu RY, Wang JM, Sun ZL, Xue XC, Yan XY, Wang JM, Zhang JH, Wang JD (2015) Transcriptional regulatory dynamics of the hypothalamic-pituitary-testicular axis in male mice exposed to fluoride. Environ Toxicol Pharmacol 40(2):557–562 CAS Article

Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

November 16, 2019 | Environmental Toxicology and P harmacology | Gao Y, Gui F, Li D, Zhang R, Sun Q, Guo X. | 73:103275 (January 2020): https://doi.org/10.1016/j.etap.2019.103275
Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/P