Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Co-exposure to Arsenic-Fluoride Results in Endoplasmic Reticulum Stress-Induced Apoptosis Through the PERK Signaling Pathway in the Liver of Offspring Rats.

November 25, 2019 | Biological Trace Element Research | Dong N, Feng J, Xie J, Tian X, Li M, Liu P, Zhao Y, Wei C, Gao Y, Li B, Qiu Y, Yan X. | doi: 10.1007/s12011-019-01975-1. [Epub ahead of print]
References 1. Wang SX, Wang ZH, Cheng XT, Li J, Sang ZP, Zhang XD, Han LL, Qiao XY, Wu ZM, Wang ZQ (2007) Arsenic and fluoride exposure in drinking water: children’s IQ and growth in Shanyin County, Shanxi Province, China. Environ Health Perspect 115(4):643–647PubMedPubMedCentralCrossRefGoogle Scholar 2. Rocha-Amador D, Navarro ME, Carrizales L, Morales R, Calderón J (2007) Decreased intelligence in children and exposure to fluoride and arsenic in drinking water. Cadernos

Evaluation of free and total fluoride concentration in mouthwashes via measurement with ion-selective electrode

November 20, 2019 | BMC Oral Health | Reshetnyak VY, Nesterova OV, Admakin OI, Dobrokhotov DA, Avertseva IN, Dostdar SA, Khakimova DF. | 19(1):251. doi: 10.1186/s12903-019-0908-0.
Abstract Background The aim of this study was to compare free fluoride concentration and total fluoride concentration in mouthwashes. Methods Fluorine-containing mouthwashes from various companies and manufacturers (Colgate Total Plax Classic Mint®, Colgate-Palmolive, New York, USA; Colgate Total Plax Gentle Mint®, Colgate-Palmolive, New York, USA; Colgate Total Plax Fresh Mint®, Colgate-Palmolive, New York, USA; Oral B Advantage®, Procter&Gamble, Cincinnati, USA; Reach

Fluoride regulates the expression of extracellular matrix HSPG and related signaling pathways FGFR3 and Ihh/PTHrP feedback loop during endochondral ossification.

November 16, 2019 | Environmental Toxicology and P harmacology | Gao Y, Gui F, Li D, Zhang R, Sun Q, Guo X. | 73:103275 (January 2020): https://doi.org/10.1016/j.etap.2019.103275
Highlights Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/PTHrP feedback loop during endochondral ossification. Abstract Fluoride promotes the expression of HSPG in growth plate of rats during endochondral ossification. Fluoride activates FGFR3 signaling pathway during endochondral ossification. Fluoride inhibits Ihh/P

Fluoride-Free Diet Stimulates Pineal Growth in Aged Male Rats.

November 12, 2019 | Biological Trace Element Research | Mrvelj A, Womble MD. | [Epub ahead of print]
References Allen DJ, DiDio LJA, Gentry ER, Ohtani O (1982) The aged rat pineal gland as revealed in SEM and TEM. Age 5(4):119–126.  https://doi.org/10.1007/BF02431274 CrossRefGoogle Scholar Bastianelli E, Pochet R (1993) Sexual dimorphism among calbindin-D28K immunoreactive cells in the rat pineal body. Histochem 100:449–455.  https://doi.org/10.1007/BF00267825 CrossRefGoogle Scholar Redecker P (1993) Dense accumulations of synaptic-like microvesicles in dark pin