References
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EXCERPTS
Strengths and limitations of the study
This is the first population-wide data linkage cohort study to evaluate the reach and impact of a complex public health intervention.
There is evidence of effectiveness of oral health improvement interventions for children including fluoride toothpaste and professionally applied fluoride varnish; however, the evidence of combining these into a complex oral health improvement programme delivered via a proportio
Highlights
Relatively low levels of fluoride exposure in US adolescents but with wide ranges.
Dose-dependent increase in prevalence of hyperuricemia with increasing fluoride levels.
Significant associations between plasma and water fluoride and hyperuricemia.
A positive relationship between water and plasma fluoride concentrations.
Potential role of chronic fluoride exposure in increased prevalence of hyperuricemia.
Abstract
Exposure to excessive fluo
This article is a preprint and has not been peer-reviewed. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.
Abstract
As a safe exposure level for fluoride in pregnancy has not been established, we used data from two prospective studies for benchmark dose modeling. We included mother-child pairs from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) cohort in M
