Tag: endocrine system

Among humans with skeletal fluorosis, fluoride may cause secondary hyperparathyroidism or cause bone damage resembling secondary hyperparathyroidism. Secondary hyperparathyroidism is a condition in which the parathyroid glands produce too much parathyroid hormone. The condition, which commonly results from kidney disease, is triggered when the levels of calcium and phosphorous in the blood are too low. In order to ensure a sufficient supply of calcium and phosphous in the blood, the parathyroid hormone (PTH) stimulates bone cells (osteoclasts) to break down the bone.