Abstract
Presented are 20 cases of Southwestern American Indians having characteristic sclerotic bone changes caused by the ingestion of drinking water containing excessively great quantities of fluoride salts. The changes of skeletal fluorosis are described, and it is pointed out that the degree of change does not seem to correlate well with the concentration of fluoride in the bone. It remains an enigma that there is such variability in the degree of the manifestations among people exposed to the same supply of drinking water,m but it is pointed out that factors such as climate, nutritional status, and habit variations may be responsible. It is concluded that skeletal fluorosis produces no demonstrable physiologic adversities, but it is important to differentiate from serious pathologic conditions which it may stimulate.
-
-
Fluorosis as a probable factor in metabolic bone disease in captive New Zealand native frogs (Leiopelma species)
This report describes the investigations into the cause and treatment of metabolic bone disease (MBD) in captive native New Zealand frogs (Leiopelma spp.) and the role of fluoride in the disease. MBD was diagnosed in Leiopelma archeyi and Leiopelma hochstetteri in 2008 at three institutions: Auckland Zoo, Hamilton Zoo, and
-
Endemic chronic fluoride toxicity and dietary calcium deficiency interaction syndromes of metabolic bone disease and deformities in India: year 2000
Epidemiological studies during 1963-1997 were conducted in 45,725 children exposed to high intake of endemic fluoride in the drinking water since their birth. Children with adequate (dietary calcium > 800 mg/d) and inadequate (dietary calcium < 300 mg/d) calcium nutrition and with comparable intakes of fluoride (mean 9.5 +/- 1.9
-
Prevalence and aetiology of juvenile skeletal fluorosis in the south-west of the Hai district, Tanzania--a community-based prevalence and case-control study
INTRODUCTION: Fluorosis is endemic throughout the East African Rift valley, including parts of Tanzania. The aim of the study was to identify all cases of deforming juvenile skeletal fluorosis (JSF) in a northern Tanzanian village and to document the extent of dental fluorosis (DF). METHODS: Door-to-door prevalence survey of all residents
-
Osteo-dental fluorosis in relation to nutritional status, living habits, and occupation in rural tribal areas of Rajasthan, India
A cross-sectional survey of 18,621 adults of both sexes living in rural tribal areas of the Dungarpur and Udaipur districts of Rajasthan, India was conducted to correlate the prevalence of osteo-dental fluorosis with nutritional status, living habits, and occupation. The mean fluoride (F) concentration in drinking water sources ranged from
-
Endemic fluorosis: a study of the factors involved in the production of mottled enamel in children and severe bone manifestations in adults
Summary and Conclusions A detailed study of the factors involved in the production of "mottled enamel" in children and severe bone manifestations in adults; as a result of the ingestion of fluorides in drinking water, has been made during the last three years. This study revealed: 1. "Mottled enamel" in children was
Related Studies :
-
-
-
Skeletal Fluorosis & Individual Variability
One of the common fallacies in the research on skeletal fluorosis is the notion that there is a uniform level of fluoride that is safe for everyone in the population. These "safety thresholds" have been expressed in terms of (a) bone fluoride content, (b) daily dose, (c) water fluoride level, (d) urinary fluoride level, and (e) blood fluoride level. The central fallacy with each of these alleged safety thresholds, however, is that they ignore the wide range of individual susceptibility in how people respond to toxic substances, including fluoride.
-
Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
-
Fluoridation, Dialysis & Osteomalacia
In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on
-
Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
-
Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
Related FAN Content :
-