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• Clinical Trial for Fluoride Supplementation to Pregnant Women

  According to the website at ClinicalTrials.gov, a study titled Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being was proposed to take place at Johns Hopkins Hospital in Baltimore, Maryland, with a start date of October 2015. Even though the website states the trial is still recruiting women, it’s unclear […]

• Oro-dental health in children with chronic renal failure and after renal transplantation: a clinical review

  Enamel hypoplasia   The pathogenesis of this is that severe metabolic upset causes a permanent mark, called enamel hypoplasia, in the developing tooth which remains as a visible defect on the tooth throughout the life of the patient. The position and extent of the defect indicates the timing, duration and to some extent the severity […]

• Alert on long-term lumbago and skelalgia not responsive to anti-rheumatic pharmacotherapy

  In our work we have often dealt with patients who were diagnosed with “rheumatic or rheumatoid arthritis” in rural basic medical units or certain hospitals. A minority of those patients did have rheumatoid arthritis, but most of them did not improve with anti-rheumatic pharmacotherapy for multiple years; instead, their conditions worsened increasingly. Some of them […]

• Renal failure and fluorosis

  It is generally agreed that water fluoridation is safe for persons with normal kidneys. Systemic fluorosis in patients with diminished renal function, however, seems a reasonable possibility. In such patients, fluoride may be retained with resulting higher tissue fluoride levels than in persons with normal renal function.

• Fluoridation and bone disease in renal patients

  About the Authors: William J Johnson, director of the Mayo Artificial Kidney Center and professor of medicine with the Division of Nephrology at the Mayo Clinic, has been involved in the study of calcium and phosphorus metabolism and renal osteodystrophy, potassium metabolism, and uremic neuropathy. He is past chairman of the Minnesota State Medical Association’s Committee […]

• The effect of 0.05 percent dietary sodium fluoride on the rat kidney

  Two hundred and twenty-six white rats were given a diet containing 0.05 per cent sodium fluoride (226 ppm) for periods ranging from 3 to 56 days. It was established that changes in the kidneys occurred regularly after 21-28 days on the diet. The kidney changes consisted primarily in dilatation of the Henle loops in the […]

• Estimation of occupational hazards of the employees of a phosphate fertilizers plant.

  In our research no essential changes in blood morphology and kidneys function were found, as well as estimation of liver efficiency was positive. The biggest number of changes which indicate toxic effect of fluorine, was found while analysing sugar curves and phosphorus-calcium-magnesium balance. Six cases of diabetes, 4 of them of early type were diagnosed, […]

• Kidney function and structure in chronic fluorosis

  An investigation has been carried out on the effects of the intake of small amounts of sodium fluoride on kidney structure and function in rats, with a view to the possibility of establishing some means of testing for the toxic effects of fluorine in human beings, and of demonstrating the existence of a fluorine hazard […]

• Endemic Goitre in the Union of South Africa and Some Neighbouring Territories.

  Authors: Douw G. Steyn, B.Sc., Dr. Med. Vet. (Vienna), D.V.Sc., Professor of Pharmacology, Medical Faculty, University of Pretoria; J. Kieser, Artseksamen (M.D.), former Chief Medical Inspector of Schools, Transvaal Provincial Administration; W.A. Odendaal, D.Sc., Research Officer in Nutrition, Union Department of Nutrition, Pretoria; H. Malherbe, M.A., M.B.Ch.B., Senior Medical Officer, Poliomyelitis Research Foundation, South African […]

• Effects of fluoride on immune system function

  “Fluoride is one of the most toxic inorganic chemicals in the Earth’s crust, but it is believed that at a concentration of 1ppm, or 1m g/mL in public water supplies, and at the concentrations used in dental preparations, it is both safe and beneficial to teeth. However, with increasing experience, doubts about both safety and […]