Among soft tissue organs which store fluoride (F-), the aorta contains the highest levels. [1-2]. Calcifications of arteries of the Monckeberg type have been reported in relatively young persons afflicted with skeletal fluorosis from endemic areas. [3-5] It was, therefore, of interest to determine whether or not there is a systematic correlation of F- levels with those of calcium (Ca++) in the aorta.
Methods. Aorta tissues were selected at random from 23 autopsies, without reference to sex,
In previous publications, cases of incipient fluorine 1) poisoning from drinking artificially fluoridated water at the 1 ppm concentration were reported. A specific disease pattern could be discerned closely tallying with what has b??n observed in industrial poisoning from fluorine intake at higher levels.
There are three groups of symptoms:
1. Those due to irritation of the organs involved in ingestion and elimination of fluorides, namely, mucous membranes of mouth, stomach, bowels and urinar
Summary
The case of ? 35-year-old woman is described presenting stiffness and severe pain in the spine, gastric disturbances, stomatitis, paresthesias in legs and arms, especially in the u1nar nerve area, loss of mental acuity, visual disturbances and extreme general malaise.
On1y ? few clear-cut objective findings were noted, namely: decreased muscular power in the ulnar nerve area, stomatitis and brittle nails. Consu1tants in various specialties felt that this patient was afflicted with an o
In a discussion of drug allergy it is necessary to distinguish between intolerance and allergy to drugs. One represents intoxication, the other is characterized by wheal formation, eosinophilia and other features of an allergic reaction. Gastric irritation, for instance, or acne from iodides or bromides represent intolerance to these drugs due to increased susceptibility of certain tissue; it cannot be associated with allergic reaction.
A discussion of allergy to halogens must establish chara
Summary
1. Further evidence based on data on 52 cases tends to confirm previous observations that fluoride-containing drinking water in concentrations around 1 ppm accounts for a characteristic clinical syndrome. Its principal manifestations are: stiffness and pains in back; paresthesias and pain in legs and arms, especially the ulnar nerve area; evidence of gastritis, stomatitis and irritation of the mucous membranes in the lower intestinal and lower urinary tract; extreme malaise and mental d
The concept that osteomalacia becomes progressively worse on chronic dialysis was reinforced by the findings in the repeat bone biopsies in that 6 of the 8 patients showed a significant increase in their osteoid index. . . . Thus, the progression of osteomalacia appears to be the main reason for the increasing incidence of bone pain and pseudofractures which we and others have observed in patients on chronic dialysis for periods longer than 6 months. Jowsey, et al, has reported similar findings.
