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Developmental toxicity evaluation of sodium fluoride administered to rats and rabbits in drinking water.

The authors comments on the Embryo–fetal effects on rats: ... Although there were no significant pairwise effects from sodium fluoride administration, the percentage of litters with one or more external malformed fetuses, the percentage of externally malformed fetuses per litter and the percentage of skeletally malformed fetuses per liter, exhibited increasing trends with increasing dose of sodium fluoride (Table 2 and 3). No significant effect were noted in the prevalence of variations in

Neurotoxicity in operating room personnel working with gaseous and nongaseous anesthesia.

Excerpt Introduction According to experimental and field studies, exposure to more than 500 ppm of nitrous oxide(N 2O) and more than 15 ppm of haJothane and enflurane can cause performance impairment in neurobehavioral exammations (Bruce and Bach 1975, 1976; Smith and Shirley 1978; Allison et al. 1979; Edling 1980; Mahoney et al. 1988. Control of exposure to anesthetic gases has received increased attention since the mid-1970s, when scavenging devices were fitted on anesthesia machines to