Discussion
A fluoride concentration of 0.2 to 3.5 ppm is sufficient to induce dental fluorosis (2). According to the data published from 1990 to 2012, it has been reported that the prevalence of fluorosis in South Africa is 47%, while in Iran it is 61% (23). Approximately 82.4% of Sri Lanka's population lives in the low fluoride region with ~80% of children experiencing mild to severe forms of dental fluorosis (24).
Intake of fluoride in an excessive amount above the safe limit is the chief
5. Conclusion
First, fluoride exposure during pregnancy and lactation may cause neurodevelopmental disorders in the offspring mice, including abnormal expression of genes related to synaptic function, and aneurotransmitters’ accumulation; the magnitude and spectrum of response to fluoride exposure in parents and offspring are significantly different.
Second, in mice exposed to fluoride during gestation and lactation, metabolic accumulation of choline and arachidonic acid and their derivati
