Abstract
Fifty four Wistar male rats were randomly divided into three groups, drinking water containing 0.6 mg/L (control group), 100 mg/L, and 200 mg/L sodium fluoride, respectively. Rats were killed at the second, fourth and sixth weeks after experiment initiation, respectively. The levels of serum testosterone, testis cholesterol, and hepatic tissue cholesterol were determined. Results showed that the serum testosterone level had decreased with time in rats drinking water containing 100 and 200 mg/L fluoride. While testis cholesterol level did not change, it was significantly decreased in the liver at the fourth and sixth week when compared with the control group. Results suggest that fluoride may have some harmful effects on the reproductive system in male rats.
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Induction of oxidative stress on reproductive and metabolic organs in sodium fluoride-treated male albino rats: protective effect of testosterone and vitamin E coadministration
The present study was undertaken to search out the effect of sodium fluoride, a water pollutant noted throughout the world, including India, on oxidative stress induction in reproductive tissues, sperm pellet, and metabolic tissues like the liver and kidney. The protective effects of testosterone or vitamin-E coadministration were also observed
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Protective effects of blackberry and quercetin on sodium fluoride-induced oxidative stress and histological changes in the hepatic, renal, testis and brain tissue of male rat
BACKGROUND: Sodium fluoride (NaF) intoxication is associated with oxidative stress and altered antioxidant defense mechanism. The present study was carried out to evaluate the potential protective role of blackberry and quercetin (Q) against NaF-induced oxidative stress and histological changes in liver, kidney, testis and brain tissues of rats. METHODS: The rats
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Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis
Highlights F and Al changed histological structure of testes, reduced sperm quality. F and Al reduced StAR and P450scc expressions and level of serum testosterone. F toxicity is stronger than Al and Al weakened the toxicity of F. Al had antagonism effects on F. A lot of studies have shown
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The effect of high fluoride intake on tissue trace elements and histology of testicular tubules in the rat
1. Male Wistar rats were exposed to fluoride (F) at concentrations of 100- and 200 ppm in their drinking water for 6- and 16 weeks. 2. The high F intake caused several-fold increase in the F concentrations in the testes and bone as compared with control rats, both after the
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Investigations of soft tissue functions in fluorotic individuals of North Gujurat
The present study was undertaken to investigate the various health problems caused by water-borne fluoride in endemic villages of Mehsana and Banaskantha districts of Gujarat. The study revealed high levels of fluoride in serum samples of the villagers. Mottling of teeth and skeletal complications were common. Intake of fluoride caused
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of overĀ 60 animal studiesĀ from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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