Tag: Benchmark dose
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NTP Research Report on Systematic Literature Review on the Effects of Fluoride on Learning and Memory in Animal Studies: Research Report 1 [Internet]
Background: Previous systematic reviews of epidemiology studies have found support for a geographical association between high levels of naturally occurring fluoride in water (>1.5 ppm) and lower IQ in children. Most of the evidence from humans is from fluoride-endemic regions having higher background levels of fluoride compared to the fluoride concentrations historically used in community […]
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A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
Discussion … The increased precision using the average maternal U-F concentration as an indicator of prenatal fluoride exposure results in stronger statistical evidence of fluoride-associated deficits, compared with using cross-sectional or retrospective studies. Still, the amount of fluoride that reaches the brain during early brain development is unknown, and even the maternal U-F concentration measurements […]
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Critical Windows of Fluoride Neurotoxicity in Canadian Children.
Discussion We used data from a prospective pregnancy and birth cohort to compare the associations between fluoride exposures during different developmental windows and preschool aged children’s intellectual abilities. The GEE method advances our understanding of early-life fluoride neurotoxicity by formally comparing strength of associations across windows of exposure. The strongest association between fluoride and child […]
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The safe exposure level to fluoride in pregnancy.
Fluoride (F) is not an essential trace element in humans or necessary for the development of healthy teeth and bones.9,10 It is likely that there is no threshold for fluoride-induced developmental neurotoxicity in drinking water, and the only assuredly safe level of fluoride in drinking water is zero.10,11,12 The currently recommended level of 0.7 mg […]
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A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.
This article is a preprint and has not been peer-reviewed. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. Abstract As a safe exposure level for fluoride in pregnancy has not been established, we used data from two prospective studies for benchmark dose […]
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Assessment of fluoride levels during pregnancy and its association with early adverse pregnancy outcomes.
Background and Aim: There is sparse data available on human subjects regarding the affect of excessive fluoride exposures on pregnancy. The aim of this study was to examine the association between elevated urinary fluoride levels during early pregnancy and maternal anemia and adverse fetal outcome. Patients and Methods: We enrolled 600 pregnant patients with gestational […]
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A quantitative analysis of chronic exposure of selected heavy metals in a model diet in a CKD hotspot in Sri Lanka.
Background Evidence of chronic low levels of exposure to heavy metals in Sri Lanka has emerged in a number of studies carried out in the recent past. The source and magnitude of such exposures have to be understood in order to assess the risk of adverse health effects of this exposure and to propose suitable […]
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Evidence of selected nephrotoxic elements in Sri Lankan human autopsy bone samples of patients with CKDu and controls.
Background This article describes the analysis and interpretation of data relating to the presence of cadmium, lead, mercury and fluoride in human bone samples obtained from cadavers of patients dying of Chronic Kidney Disease of uncertain aetiology (CKDu) in a case-control study, which the authors believe to be the first in Sri Lanka. Methods This […]
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Developmental fluoride neurotoxicity: an updated review.
Background After the discovery of fluoride as a caries-preventing agent in the mid-twentieth century, fluoridation of community water has become a widespread intervention, sometimes hailed as a mainstay of modern public health. However, this practice results in elevated fluoride intake and has become controversial for two reasons. First, topical fluoride application in the oral cavity […]
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Estimation of potential health effects from acute exposure to hydrogen fluoride using a “benchmark dose” approach.