Abstract
Objective: To study the effect of excessive fluoride intake on the function of pancreatic islet’s B cells.
Methods: We performed x-rays, determined the [F] in the urine, conducted OGTT insulin and C-peptide releasing tests in the serum, and analyzed the drinking water quality of the exposed group and control group.
Results: (1) The [F] in drinking water and the geometrical mean of the [F] in the urine of the people of the exposed group were higher than those of the control group. (2) The fasting blood glucose concentration and the peak value after oral glucose in the exposed group were higher than those of the control group. The peak value was found later in the exposed group than in the control group. (3) The detectable rate of Diabetes and IGT in the exposed group was higher than that in the control group. (4) The blood-insulin and C-peptide in the exposed group were lower than in the control group, although the peak value after oral glucose was found later in the exposed group.
Conclusions: Excessive fluoride can do much harm to the function of the pancreas islet B cells and the effects change with the degree of fluorosis.
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Elevated serum fluoride levels in perimenopausal women are related to the components of metabolic syndrome.
OBJECTIVE: Increased fluoride levels can lead to numerous complications, including skeletal effects, cardiotoxicity, endocrine dysfunction, neurotoxicity, hepatotoxicity and nephrotoxicity. The aim of this study was to analyze the relationship between serum fluoride levels and MetS or its individual components, and to assess the diagnostic usefulness of fluoride as a factor contributing to
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Activity of pancreatic antioxidative enzymes and malondialdehyde concentrations in rats with hyperglycemia caused by fluoride intoxication.
The aim of this work was to examine the effect of fluoride ions on antioxidative enzyme activity in the pancreas of rats exposed during 4 months to NaF in drinking water. The study was carried out in 30 four-week-old male Wistar FL rats, that were randomly assigned to three equal
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Chronic fluoride’s impact on pancreatic islet cells in workers.
Decreasing of the insulin concentration and increasing of the C-peptide level in blood serum of 72 workers of cryolytes industries detected by radioimmunilogical method. These changes were caused by the fluorine intoxication of workers.
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Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the
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Inorganic plasma fluoride concentrations and its renal excretion in certain physiological and pathological conditions in man
In a study involving 2200 patients the inorganic plasma fluoride concentration (IPFC) increased with increasing age. In a fluoridated (1 ppm) community this increase was more pronounced than in a low fluoride (0.2 ppm) community. The mean renal clearance of fluoride and the daily amounts excreted also increased slightly until
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NRC (2006): Fluoride's Effect on Glucose Metabolism
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