Abstract
The relation between fluoride level in drinking water and the incidence of congenital heart disease in Iowa was studied by means of a hybrid case-control design. Controls (n = 2,172) were randomly selected from the birth tapes of the State of Iowa between January 1, 1983 and December 31, 1987, and frequency matched by time of conception with cases of intracardiac blood flow defect (n = 543) ascertained through the Birth Defects Registry of lowa. Potential confounding factors included levels of nitrate in drinking water, chlorination status and source of drinking water, demographic characteristics of parents, gestational age, and birth weight of infants. Logistic regression analysis yielded an adjusted odds ratio of 1.58 (95% confidence-interval (CI) 1.10-2.26) for fluoride exposure. With further adjustment for the percentage of farming population in the maternal county of residence, a variable highly correlated with fluoride exposure, the adjusted odds ratio was 1.15 (95% CI 0.79-1.77). These results suggest that further studies are warranted to evaluate the effects of farming and fluoride in drinking water on the occurrence of intracardiac blood flow defects.
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Relationship between fluoride deposition and metastatic calcification in soft tissues of rat and guinea pig
Two studies have been conducted to investigate whether there is a relationship between the disposition of fluoride in various soft tissues of rats and guinea pigs and the levels of calcium and phosphorous in the tissues. The results suggest that when rats receive a stock corn diet there is a
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Studies on the toxicology of fluorine compounds. I. Histological and histochemical investigations on the liver, heart, lungs, and stomach of rats exposed to hydrogen fluoride.
The liver, heart, lungs, and stomach of rats exposed to hydrogen fluoride were studied. Histological examination showed partial liver necrosis and emphysema. Using histochemical methods the effect of fluorine ions was found in: a reduction of the activity of succinic and beta-hydroxybutyric dehydrogenases in the liver, heart muscle, superficial and
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The effects of fluoridated water on rat urine and tissue cAMP levels
Male Wistar rats were fed a fluoride deficient diet (less than 0.5 parts/10(6) F), and either distilled water or fluoridated water (1.0 parts/10(6)). By week 3, the control group had urinary excretions of 106 +/- 5 nmol cAMP/day (mean +/- SEM) whereas the experimental group excreted 129 +/- 6 nmol
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Marked hypocalcemia and ventricular fibrillation in two pediatric patients exposed to a fluoride-containing wheel cleaner
In two separate cases, pediatric patients exposed to Armor-All Quicksilver Wheel Cleaner exhibited systemic toxicity including mental status changes, marked hypocalcemia, and ventricular fibrillation. One child also demonstrated profound hypomagnesemia. These are the first pediatric reports of near-fatal outcomes after ingestion or inhalation of a hydrofluoric acid-like product, namely, ammonium
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The effects of the inhalation of hydrogen fluoride. I. The response following exposure to high concentrations.
The effects of inhalation exposure to hydrogen-fluoride (7664-39-3) (HF) were examined in New-Zealand-white-rabbits and guinea-pigs. Animals were exposed to HF in enclosed chambers at concentrations ranging from 8 to 0.024 milligrams per liter (mg/l) for 5 minutes to 41 hours. Mortality rates were recorded, general physical conditions were monitored, and
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Fluoride & Myocardial Damage
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Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
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Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
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Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
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Fluoride & Arteriosclerosis
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