Abstract
Addition of NaF or MFP to rat hepatocytes resulted in a decrease in lactate and in an increase in glucose, 3 and 2-phosphoglycerate production. When dihydroxyacetone was present in the incubation medium both NaF and MFP increased the production of glucose, fructose-1,6-diphosphate, 3 and 2 phosphoglycerate, with a decrease in pyruvate and lactate. In the presence of lactate, glucose production increased only in the presence of MFP, but there was a 8–10 fold increase in the level of phosphoenol pyruvate with both NaF and MFP. The crossover data indicated that the activity of some of the glycolytic enzymes may be inhibited in the presence of NaF and MFP.
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Gluconeogenesis and glycogenolysis in fluoride-treated rats.
Intraperitonial administration of 10 mg fluoride (NaF)/kg body weight resulted in hyperglycemia in rats. Role of gluconeogenesis and glycogenolysis in this hyperglycemic response was evaluated. Results of the study indicate that the fluoride induced hyperglycemia is mainly due to increased hepatic glycogenolysis.
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Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations
OBJECTIVES: Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and
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Influence of extended exposure to sodium fluoride and caffeine on the activity of carbohydrate metabolism enzymes in rat blood serum and liver.
A 50-day study of the influence of fluoride (F) and caffeine on carbohydrate metabolism enzymes was conducted on 18 male Sprague-Dawley rats, 4.5 months old, housed in separate cages at 22–25°C on a 12-hr light/dark cycle. The rats were divided into three groups with six rats in each group: control,
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Oxidative stress induced by fluoride in adult mice and their suckling pups.
To assess renal and liver damages in pregnant and lactating mice as well as in their suckling pups, Wistar female mice were given 500 ppm NaF (226 ppm F-) in drinking water from the 15th day of pregnancy until day 14 after delivery. All mice were sacrificed on day 14
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Studies on effects of fluoride in 36 villages of Mehsana District, North Gujurat"
A survey was carried out in 36 fluoride endemic villages of Mehsana District of North Gujarat. Urine and blood samples of fluoride-afflicted human population and their drinking water were analysed for fluoride content and compared with samples from different parts of Ahmedabad city (control). The fluoride content in water samples
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