Abstract
Fluorides are commonly added to drinking water in the United States to decrease the incidence of dental caries. Silicofluorides, such as sodium hexafluorosilicate (Na2 SiF6 ) and fluorosilicic acid (H2 SiF6 ), are mainly used for fluoridation, although fluoride salts such as sodium fluoride (NaF) are also used. Interestingly, only the toxicity of NaF has been examined and not that of the more often used silicofluorides. In the present study, the toxicities of NaF, Na2 SiF6 , and H2 SiF6 were compared. The toxicity of these fluorides on the growth, feeding, and reproduction in the alternative toxicological testing organism Caenorhabditis elegans was examined. Exposure to these compounds produced classic concentration-response toxicity profiles. Although the effects of the fluoride compounds varied among the 3 biological endpoints, no differences were found between the 3 compounds, relative to the fluoride ion concentration, in any of the assays. This suggests that silicofluorides have similar toxicity to NaF.
*Original abstract with references online at https://europepmc.org/article/MED/24105802#funding
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Toxic effects of silicofluoridated water in chinchillas, caimans, alligators, and rats held in captivity
Two independent experiences with animals in captivity revealed a dramatic onset of severe debilitating symptoms when the nonfluoridated water supplies were changed to municipal water fluoridated with fluorosilicic acid, H2SiF6. The first group of animals, chinchillas in a small fur farm operation, quickly more than doubled their water consumption with the change to silicofluoridated
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Impact of 12-week ingestion of sodium fluoride on agression, sexual behavior, and fertility in adult male rats.
Ingestion of sodium fluoride at 100 and 300 ppm in drinking water for 12 weeks by adult male Sprague-Dawley rats was investigated for effects on territorial aggression, sexual behavior, and fertility. Body weight and absolute and relative testes weights were not affected, but the average weights of epididymis, ventral prostate,
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Fluoride impairs oocyte maturation and subsequent embryonic development in mice.
The damage caused by fluorosis is permanent, and has been recognized as a public health problem in a number of regions of the world. Although multiple studies provided evidence that sodium fluoride (NaF) elicits adverse effects on reproductive function, the effect of fluoride on female germ cell development is not
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Effect of intratesticular injection of sodium fluoride on spermatogenesis
The potential of sodium fluoride to affect spermatogenesis in the rat was assessed by intratesticular injection. Experimental rats' left testis was injected with sodium fluoride (50, 175 and 250 ppm) in vehicle (0.9% physiological saline); control testes were injected with vehicle. The right testis served as a non-injected control. Testicular
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Effects of sodium fluoride on reproductive function in female rats
The aim of this study was to investigate the effects of sodium fluoride (NaF) on female reproductive function and examine the morphology of the ovaries and uteri of rats exposed to NaF. Eighty female Sprague-Dawley (SD) rats were divided randomly into four groups of 20: one control group and three
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
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Fluorine recovery in the fertilizer industry - a review.
The fluorine compounds liberated during the acidulation of phosphate rock in the manufacture of phosphoric acid and fertilizers are now rightly regarded as a menace, and the industry is now obliged to suppress emissions of fluorine-containing vapours to within very low limits in most parts of the world. As with any pollution control operation, it is highly desirable for the operator of the fluorine scrubbing operation to find a use or market for the recovered fluorine to help defray at least partially the cost of the operation.
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Fluoride's Effect on Male Reproductive System: Animal Studies
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Westendorf's Research on Incomplete Dissociation of Silicofluorides Under Physiological Conditions
The Kinetics of Acetylcholinesterase Inhibition and the Influence of Fluoride and Fluoride Complexes on the Permeability of Erythrocyte Membranes Dissertation to receive Ph.D. in Chemistry from the University of Hamburg By Johannes Westendorf Hamburg, Germany - 1975 (Click here to read Westendorf's thesis) Reviewer: Prof Dr. A. Knappwost Co-Reviewers: Prof, Dr, Malomy Prof, DR, Strehlow Prof, Dr. Hilz Prof Dr. Gercken The
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