Abstract
Daily dosages of 5 and 10 mg NaF/kg bw were administered orally to male rats (15 per group) for 60 days to evaluate the effect on the testis in relation to oxidative stress. A significant decrease in body and organ weights occurred compared to controls. Alterations in the antioxidant indices in the testis were confirmed by increased lipid peroxidation (LPO) along with decrements in antioxidant parameters such as glutathione peroxidase (GPx), glutathione (GSH), total ascorbic acid (TAA), glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) levels affecting testis function as indicated by histopathological study. Supplementation of the NaF-treated rats by the antioxidant melatonin (10 mg/kg bw) revealed a significant protection to the gonadal function, thus indicating a mitigating effect by melatonin against NaF- induced testis toxicity and oxidative stress in a rat model.
-
-
Clofibrate, a Peroxisome Proliferator-Activated Receptor-Alpha (PPAR?) Agonist, and Its Molecular Mechanisms of Action against Sodium Fluoride-Induced Toxicity.
Sodium fluoride (NaF) is one of the neglected environmental pollutants. It is ubiquitously found in the soil, water, and environment. Interestingly, fluoride has been extensively utilized for prevention of dental caries and tartar formation, and may be added to mouthwash, mouth rinse, and toothpastes. This study is aimed at mitigating
-
Effects of sodium fluoride and sulfur dioxide on oxidative stress and antioxidant defenses in rat testes
To assess effects of sodium fluoride and sulfur dioxide on oxidative stress and antioxidant defenses in the testes, 96 sexually mature male Wistar rats were divided randomly into four groups of twenty-four rats each. One group of rats was left untreated as controls, and the other three groups were administered,
-
Testicular toxicity in sodium fluoride treated rats: association with oxidative stress
This study examined the effect of sodium fluoride, a water pollutant important through the world, including India, on testicular steroidogenic and gametogenic activities in relation to testicular oxidative stress in rats. Sodium fluoride treatment at 20mg/kg/day for 29 days by oral gavage resulted in significant diminution in the relative wet
-
Sodium fluoride causes oxidative damage to silkworm (Bombyx mori) testis by affecting the oxidative phosphorylation pathway.
Highlights Fluoride induced reproductive damage in silkworms is closely linked to the oxidative phosphorylation pathway. The root cause of ROS formation is increased activity of mitochondrial complexes I, III, IV and V in the silkworm testis. The accumulation of ROS (H2O2 and O2-) in the testis may be the
-
Effects of Fluoride on SOD and CAT in Testis and Epididymis of Mice.
Oxidative damage has been implicated to be one of main mechanisms by which fluoride (F) induces toxic effects. Previous studies reported that F destroyed the epididymal structure of mouse and rabbit. Epididymis is the important place for sperm maturation. However, little is known about the effect of F on the
Related Studies :
-
-
-
Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
-
Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
-
Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
-
Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
-
Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
Related FAN Content :
-