Abstract

Design: Multi-centre split mouth randomised controlled trial. Intervention Following prophylaxis, isolation, etching and drying the allocated resin-based fissure sealant (RBS) was applied according to the manufacturer’s instructions. Reviews were undertaken by a blinded observer at 6,12,18 and 24 months. Operators and observers were calibrated for ICDAS .

Outcome measure:  The primary outcome was the presence of an ICDAS (International Caries Detection and Assessment System) 3-6 lesion on sealed tooth during the two-year follow-up. Sealant retention was a secondary outcome.

Results:  Four hundred children (663 tooth pairs) were randomised, 290 children (483 tooth pairs) completed the two-year follow up. There was a lower risk of ICDAS 3-6 lesions in sealed molars; Hazard ratio [HR] = 0.16 (95% CI: 0.14 – 0.19). The effect was similar for both fluoride; HR= 0.15 (95% CI: 0.12 – 0.19) and non-fluoride sealants; HR= 0.18 (95% (CI: 0.15 – 0.21)

Conclusions: Sealant placement reduced the risk of ICDAS 3-6 lesions at 24 months; similar reductions in caries were seen for fluoride and non-fluoride sealants.

• Related Studies :

  • Toxicity and effect of whitening toothpastes on enamel surface.

    Abstract This in vitro study evaluated the biocompatibility and abrasivity of whitening and conventional toothpastes. Samples of conventional (non-whitening) - Edel White Infant (EWI) - and whitening toothpastes - Edel White Whitening (EWW), Edel White CAREFORTE (EWC), Colgate Total 12 Ò Professional (C), and Oral-B Whitening (OB) - were dissolved in

  • Assessing fluoride levels of carbonated soft drinks

    BACKGROUND: Dental fluorosis occurs as a result of excessive total fluoride intake during tooth development. Some children may receive substantial intake from soft drinks, but few studies have reported fluoride levels in soft drinks. The authors examined the fluoride concentrations of 332 soft drinks. METHODS: Soft drinks were purchased from Iowa

  • Enhancement of inflammation by fluorides

    Application of ammonium fluoride under an occlusive patch to the abdomen of a rabbit converts a simple scratch into a double row of sterile pustules. Sodium fluoride produces a similar response, but ammonium chloride does not produce pustules. . . . It appears that tissue damage and the presence of fluorides

  • Perioral dermatitis

    Since its description in 1957 by Frumess and Lewis (1) as a "light-sensitive seborrheid," perioral dermatitis (PD) has been a perplexing entity. It characteristically presents as a chronic eruption consisting of papules and pustules that develop on irregular areas of erythema and edema. the eruption is most prominent in the

  • Controlling the fluoride dosage in a patient with compromised salivary function

    BACKGROUND:  High-concentration topical fluorides are used commonly to with compromised salivary function due to irradiation and chemotherapy. CASE DESCRIPTION:  The authors describe a 50-year-old man with previously treated cancer who was using tray-applied topical fluoride gel. He complained of gastric symptoms, difficulty in swallowing, leg muscle soreness and knee joint soreness.