Abstract
Highlights
- The relative species abundance of intestinal fungi in mice was affected by fluoride.
- Fluoride mainly affected intestinal fungi in mice at the genus level.
- There was a strong positive correlation between Penicillium and Pluteus.
To explore the effects of fluoride on intestinal fungi in mice, the internal transcriptional spacer (ITS) region in colon feces of mice exposed to 100 mg sodium fluoride (NaF)/L of distilled water for 60 days were sequenced. Results showed that, there were 305 operational taxonomic units (OTUs) unique to the control group, 154 OTUs to the fluoride group, and 295 OTUs were detected in both groups. There was no significant difference in relative species abundance between the two groups at phylum levels. Compared with control group, Ustilaginomycetes class, showed a significant change in fluoride group. At the genus level, Epicoccum, Penicillium, Microdochium, Plectosphaerella and Pluteus were significantly affected by fluoride exposure. Among them, there was a strong positive correlation between Penicillium and Pluteus (+0.43). Therefore, it showed that fluoride can influence the relative species abundance of intestinal fungi in mice, mainly at the genus levels. It can provide some new ideas about the harmful effects of fluorosis on intestinal fungal homeostasis.
Graphical abstract
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Studies of human gastric mucosa after application of 0.42% fluoride gel
Dental prophylaxis with APF gels (1.23%) may cause gastric distress as a side-effect. This gastric irritation is probably due to a direct toxic effect of fluoride (F), swallowed in conjunction with the treatment, on the gastric mucosa. The aim of the present study was to investigate whether--and to what extent--a
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Prenatal and postnatal ingestion of fluorides: fourteen years of investigation -- final report*.
SUMMARY Data is presented showing that fluoride ingested by gravid women enters the maternal circulation, is stored in the placenta and passes through the placental barrier to enter the foetal blood supply. Evidence is presented that the fluoride in the foetal blood supply affects the developing teeth to make them more resistant
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Tissue response of gastric mucosa after ingestion of fluoride
Fluoride has been used successfully to prevent dental caries and has also been used to treat osteoporosis. Doses of sodium fluoride of about 50 mg a day have long term beneficial effects on the mineral content of bone and the incidence of fracture. (1) These doses, however, have resulted in
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Fluoride exposure and bone status in patients with chronic intestinal failure who are receiving home parenteral nutrition
BACKGROUND AND OBJECTIVE: Metabolic bone disease is frequent in chronic intestinal failure. Because fluoride has a major effect on bones, the status of both fluoride and bone was studied in long-term home parenteral nutrition (HPN) patients. DESIGN: We studied 31 adults aged (x +/- SD) 56.3 +/- 15.1 y, mainly
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Gastric discomforts from fluoride in drinking water in Sanganer Tehsil, Rajasthan, India
A health survey of 1135 children and 1475 adults living in Sanganer Tehsil, Rajasthan, India, revealed a wide range of gastrointestinal (GI) discomforts associated with fluoride (F) in the groundwater in over 30 village areas. Complaints of abdominal pain including stomach ache, a bloated feeling, nausea, diarrhea, and constipation were
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