Research Studies
Study Tracker

Study Tracker

The most up-to-date and comprehensive source for studies on fluoride's multifaceted effects on human and animal health, with 100+ years of research organized by health category, type of study, author, journal, and date.
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Evaluation of water fluoridation scheme in Cumbria: the CATFISH prospective longitudinal cohort study.

November 13, 2022 | Public Health Research | Goodwin M, Emsley R, Kelly MP, Sutton M, Tickle M, Walsh T, Whittaker W, Pretty IA. | 10:11.
Plain English summary Tooth decay is the most common disease of childhood, and tooth extraction due to decay is the main reason why children have a general anaesthetic in hospital. It is known that fluoride can prevent tooth decay and can be provided via the water. Research in the USA and UK in the 1940s/50s showed that water fluoridation produced dramatic falls in tooth decay. However, the introduction of fluoride toothpaste in the 1970s also caused large reductions  in dental decay. We under

The CATFISH study protocol: an evaluation of a water fluoridation scheme.

February 1, 2016 | BMC Oral Health | Goodwin M, Emsley R, Kelly M, Rooney E, Sutton M, Tickle M, Wagstaff R, Walsh T, Whittaker W, Pretty IA. | 16:8.
Abstract Background Tooth decay is the commonest disease of childhood. We have known for over 90 years that fluoride can prevent tooth decay; it is present in nearly all toothpastes and can be provided in mouthwashes, gels and varnishes. The oldest method of applying fluoride is via the water supply at a concentration of 1 part per million. The two most important reviews of water fluoridation in the United Kingdom (the York Review and MRC Report on water fluoridation and health) conclud

Estrogen deficiency aggravates fluoride-induced small intestinal mucosa damage and junctional complexes proteins expression disorder in rats.

November 1, 2022 | Ecotoxicology and Environmental Safety | Jin Y., Gao X., Zhao J., Tian W., Zhnag Y., Tian E., Zhao B., & Wang H. | 246
Highlights Fluoride damaged intestinal epithelial cells. Fluoride inhibited intestinal epithelial cells proliferation. Fluoride disrupted expression of junctional complexes proteins. Fluoride reduced glycoproteins secretion. Estrogen deficiency exacerbated fluoride-induced enterotoxicity. *Original full-text article online at: https://www.sciencedirect.com/science/article/pii/S0147651322010211?via%3Dihub

Fluoride induced leaky gut and bloom of Erysipelatoclostridium ramosum mediate the exacerbation of obesity in high-fat-diet fed mice.

October 29, 2022 | Journal of Advanced Research | Chen G. et al |
Highlights Fluoride exacerbates obesity in HFD fed mice, while shows limited effect in ND mice. Fluoride induced obesity is mediated by gut microbiota and intestinal barrier. Fluoride exacerbates the obesity in HFD mice through a TLR4-dependent mechanism. Erysipelatoclostridium ramosum was identified as a crucial mediator of fluoride induced obesity. *Original full-text article online at: https://www.sciencedirect.com/science/article/pii/S2090123222002399